Mental health disorders touch rich and poor, young and old, in every country around the world. In the first episode of an audio show published by Nature Journal in collaboration with Grand Challenges, three experts, including Dr. Rabih El Chammay, head of the National Mental Health Programme at the Ministry of Public Health in Lebanon, discuss the evidence for interventions, how to get help to the right people, and which challenge, if solved, would help the most. In addition to discussing the priorities in global mental health, Dr. Chammay highlights the work being done by the MOPH in reforming the mental health system in Lebanon.